Results
Performance Table
Program ![]() | CPU time ![]() | Seq ID ![]() | Free energy ![]() | Covar. ![]() | Bp. prob. ![]() | Canonical bp. ![]() | SPS ![]() | SEN ![]() | PPV ![]() | MCC ![]() |
|---|---|---|---|---|---|---|---|---|---|---|
| Consensus | 0.00 | 0.40 | -16.70 | 0.93 | 0.56 | 0.95 | 0.89 | 0.94 | 0.94 | 0.94 |
| CMfinder | 4.65 | 0.40 | -13.79 | 0.81 | 0.52 | 0.91 | 0.74 | 0.85 | 0.86 | 0.83 |
| FoldalignM | 30.92 | 0.37 | -16.84 | 0.95 | 0.57 | 0.95 | 0.74 | 0.90 | 0.91 | 0.89 |
| LaRA | 58.00 | 0.40 | -18.63 | 1.03 | 0.59 | 0.97 | 0.87 | 0.96 | 0.96 | 0.95 |
| LocARNA | 7.68 | 0.41 | -16.22 | 0.93 | 0.63 | 0.92 | 0.84 | 0.73 | 0.96 | 0.82 |
| MASTR | 170.05 | 0.42 | -17.22 | 0.88 | 0.58 | 0.94 | 0.86 | 0.93 | 0.94 | 0.92 |
| MXSCARNA | 0.59 | 0.39 | -15.87 | 0.68 | 0.56 | 0.92 | 0.81 | 0.90 | 0.91 | 0.89 |
| MURLET | 57.97 | 0.43 | -9.23 | 0.90 | 0.70 | 0.98 | 0.85 | 0.57 | 1.00 | 0.73 |
| RNASampler | 96.54 | 0.37 | -19.38 | 1.07 | 0.59 | 0.98 | 0.82 | 0.98 | 0.98 | 0.98 |
| RNAforester | 0.28 | 0.24 | -4.67 | 0.32 | 0.46 | 0.66 | 0.32 | 0.36 | 0.57 | 0.35 |
| PETfold | 2.76 | 0.37 | -6.02 | 0.37 | 0.45 | 0.73 | 0.65 | 0.64 | 0.62 | 0.56 |
| ClustalW-Pfold | 0.04 | 0.38 | -5.15 | 0.60 | 0.38 | 0.86 | 0.61 | 0.53 | 0.74 | 0.59 |
| ClustalW-RNAalifold | 0.07 | 0.38 | -7.03 | 0.66 | 0.38 | 0.87 | 0.61 | 0.51 | 0.76 | 0.58 |
| MAFFT-Pfold | 0.98 | 0.38 | -14.59 | 0.85 | 0.61 | 0.92 | 0.78 | 0.82 | 0.89 | 0.84 |
| MAFFT-RNAalifold | 1.05 | 0.38 | -15.10 | 0.90 | 0.65 | 0.92 | 0.78 | 0.70 | 0.90 | 0.77 |
Cluster tree of the methods
| Table | Consensus | CMfinder | FoldalignM | LaRA | |
| LocARNA | MASTR | MXSCARNA | Murlet | RNASampler | RNAforester |
| Stral+PETfold | ClustalW+Pfold | ClustalW+RNAalifold | MAFFT+Pfold | MAFFT+RNAalifold |
References
If you use the consensus results generated by this web server, please cite (bibtex):
Torarinsson, E. and Lindgreen, S. (2008): WAR: Webserver for aligning structural RNAs, Nucleic Acids Res., Web Server Issue, W79-84 [Link to paper]
C. Notredame, D. Higgins and J. Heringa (2000): T-Coffee: A novel method for multiple sequence alignments, J. Mol. Biol., 302(1):205-217 [Link to paper]
Z. Yao, Z. Weinberg, and W. L. Ruzzo (2006): CMfinder - a covariance model based RNA motif finding algorithm, Bioinformatics, 22(4):445-452 [Link to paper]
E. Torarinsson, J. Havgaard, and J. Gorodkin (2007): Multiple structural alignment and clustering of RNA sequences, Bioinformatics, 23(8):926-932 [Link to paper]
M. Bauer, G. W. Klau, and K. Reinert (2007): Accurate multiple sequence-structure alignment of RNA sequences using combinatorial optimization, BMC Bioinformatics, 8(271) [Link to paper]
S. Lindgreen, P. Gardner, and A. Krogh (2007): MASTR: Multiple alignment and structure prediction of non-coding RNAs using simulated annealing, Bioinformatics, doi: 10.1093/bioinformatics /btm525 [Link to paper]
I. L. Hofacker, M. Fekete, and P. F. Stadler (2002): Secondary structure prediction for aligned RNA sequences, Journal of Molecular Biology, 319(5):1059-1066 [Link to paper]
J. D. Thompson, D. G. Higgins, and T. J. Gibson (1994): CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penal ties and weight matrix choice, Nucleic Acids Research, 22(22):4673-4680 [Link to paper]
M. Höchsmann, T. Töller, R. Giegerich and S. Kurtz (2003): Local similarity of RNA secondary structures, in Proc. of the IEEE Bioinformatics Conference, 159-168 [Link to paper]
J. Reeder and R. Giegerich (2005): Consensus shapes: An alternative to the Sankoff algorithm for RNA consensus structure prediction, Bioinformatics, 21(17):3516-3523 [Link to paper]
X. Xu, Y. Ji, and G. Stormo (2007): RNA Sampler: A new sampling based algorithm for common RNA secondary structure prediction and structural alignment, Bioinformatics, 23(15):1883- 1891 [Link to paper]
S. Will, K. Reiche, I.L. Hofacker, P.F. Stadler and R. Backofen (2007): Inferring non-coding RNA families and classes by means of genome-scale structure-based clustering, PLOS Comp. Bio., 3(4):e65. doi:10.1371/journal.pcbi.0030065 [Link to paper]
H. Kiryu, Y. Tabei, T. Kin and K. Asai (2007): Murlet: A practical multiple alignment tool for structural RNA sequences, Bioinformatics, 23(13):1588-1598. doi:10.1093/bioinformatics/btm146 [Link to paper]
Y. Tabei, H. Kiryu, T. Kin and K. Asai (2008): A fast structural alignment method for long RNA sequences, BMC Bioinformatics, 9(33):doi: 10.1186/1471-2105-9-33 [Link to paper]
K. Asai, H. Kiryu, M. Hamada, Y. Tabei, K. Sato, H. Matsui, Y. Sakakibara, G. Terai and T. Mituyama (2008): Software.ncrna.org: web servers for analyses of RNA sequences, Nucleic Acids Res., Web Server Issue, 36:W75-W78 [Link to paper]
D. Dalli, A. Wilm, I. Mainz and G. Steger (2006): StrAl: Progressive alignment of non-coding RNA using base pairing probability vectors in quadratic time., Bioinformatics, 22:1593-1599 [Link to paper]
S. Seemann, J. Gorodkin, and R. Backofen (2008): Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments., Nucleic Acids Res., 36:6355-6362 [Link to paper]
B. Knudsen and J. Hein (2003): Pfold: RNA secondary structure prediction using stochastic context-free grammars, Nucleic Acids Res., 31(13):3423-3428 [Link to paper]
K. Katoh, K. Misawa, K. Kuma and T. Miyata (2002): MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform, Nucleic Acids Res., 30:3059-3066 [Link to paper]
If you only use the results from a single prediction please cite us (WAR) and the respective program.
